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    Affiliations 1 EU Research and Non Clinical Safety R D Sanofi Pasteur Campus Mérieux 69280 Marcy l Etoile France 2 Assistant Professor of Pediatrics Sidney Kimmel Medical College at Thomas Jefferson University Division of Infectious Diseases Nemours/Alfred I duPont Hospital for Children Wilmington Delaware 19803 3 Emeritus Professor of Pediatrics University of Pennsylvania

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    The co stimulatory molecule CD28 is essential for activation of helper T cells Despite this critical role it is not known whether CD28 has functions in maintaining T cell responses following activation To determine the role for CD28 after T cell priming we generated a strain of mice where CD28 i

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